{"product_id":"methylation-profile-dna","title":"DNA Methylation Profile","description":"\u003cp dir=\"auto\"\u003eDoctor’s Data, Inc. has served healthcare practitioners from its CLIA-licensed laboratory in St. Charles, Illinois, since 1972. Alongside its functional chemistry panels, the laboratory offers targeted SNP screening for pathways involved in methylation, detoxification, neurotransmitter clearance, nitric oxide, and vitamin D signalling. The DNA Methylation Pathway Profile is the buccal-swab version of that screen — a home collection that identifies predisposition, not current function.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eThe profile looks for single-nucleotide polymorphisms that can change how enzymes in methionine metabolism and related pathways work. These are common sequence variants, not rare disease mutations. A SNP may increase the risk of inefficient folate cycling, slower remethylation of homocysteine, altered transsulfuration, or altered COMT\/MAO handling of catecholamines. It does not, by itself, tell you whether that pathway is failing in this patient today. Diet, nutrients, toxicant load, stress and age all modify expression. Lead and BPA can inhibit methyltransferases; mercury can inhibit methionine synthase. That is why Doctor’s Data positions this swab as the genetic map and the \u003cstrong\u003ePlasma Methylation Profile\u003c\/strong\u003e as the functional follow-up when methionine-pathway SNPs are present.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eClinically, the panel is used when you need a compact view of variants that touch insulin sensitivity, bone and vitamin D status, cardiovascular risk, detoxification capacity, fertility, mitochondrial metabolism, methylation itself and neurotransmitter balance. Results can shape where you look next — methylfolate versus folinic, B12 form, betaine, B6, molybdenum, or whether COMT status should slow how aggressively you methylate — but intervention should still be titrated against symptoms and, where relevant, plasma SAM, SAH, homocysteine and the SAM:SAH index.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eUse the swab to see what the patient is carrying. Use plasma metabolites to see what those genes are doing.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch3 dir=\"auto\"\u003eTest specifications\u003c\/h3\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eSample type:\u003c\/strong\u003e Buccal swab (at home; no fasting)\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eTurnaround time:\u003c\/strong\u003e2-3 Weeks\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eKey markers — \u003c\/strong\u003eMTHFR (C677T, A1298C, MTHFR-3); MTR (A2756G); MTRR (A66G, H595Y, K350A, R415T, S257T, MTRR-11); SHMT (C1420T); BHMT (1, 2, 4, 8); AHCY (1, 2, 19); ACAT (1-02)\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0578\/1287\/7465\/files\/Sample_Report_Methylation_1.pdf?v=1788844656\" title=\"Doctors Data Methylation Profile Buccal Swab\"\u003e\u003cstrong\u003eSample Report \u003c\/strong\u003e\u003c\/a\u003e\u003cbr\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0578\/1287\/7465\/files\/Sample_Report_SNP_1.pdf?v=1788846083\" title=\"Doctors Data Methylation Buccal Swab Collection Instructions\"\u003eCollection Instructions\u003c\/a\u003e\u003c\/p\u003e","brand":"Doctors Data","offers":[{"title":"Default Title","offer_id":48994084749465,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0578\/1287\/7465\/files\/Screenshot2026-09-08at1.38.54PM.png?v=1788845960","url":"https:\/\/www.lablink.asia\/en-th\/products\/methylation-profile-dna","provider":"Lab Link","version":"1.0","type":"link"}