ALEX³ Comprehensive IgE Allergy Test - NEW

Forensic Genomics Innovation Hub (FGIH) has provided clinically oriented diagnostic testing from its UK laboratory, supporting both healthcare practitioners and individuals seeking high-resolution insights into immune responses. Best known for its work in forensic genomics and functional health testing, the laboratory offers the Allergy Solution – ALEX³ Comprehensive IgE Allergy Test, the new-generation upgrade of the earlier ALEX² assay.

It measures specific IgE against a broad panel of allergen extracts and molecular components. This allows clinicians to see how the immune system is actually responding to individual proteins, not only which allergen sources are present.

What it Covers and why it's clinically relevant

Normal immune tolerance keeps the body from mounting an IgE response to harmless substances such as pollens, foods, animal dander, mites, moulds, and insect venoms. When this tolerance breaks down, IgE antibodies form and can trigger symptoms ranging from rhinitis and eczema to gastrointestinal reactions or anaphylaxis. Problems can appear at any age and are influenced by genetics, environmental exposure, barrier function, and co-factors. Traditional extract-based testing shows sensitisation to whole allergen sources (for example, apple or birch pollen). The ALEX³ panel goes further by also measuring molecular allergens—specific protein components within those sources so cross-reactions (such as pollen–food syndromes) and heat-stable versus heat-labile allergens can be identified. This phenotypic information is useful both at baseline and for guiding and monitoring dietary, environmental, or immunotherapy strategies.

The panel reports specific IgE levels for 300 allergens (82 allergen extracts and 218 molecular allergens), covering 80 allergen families and 145 allergen sources, plus a semi-quantitative total IgE result. Molecular allergens help distinguish true primary sensitisation from cross-reactivity, assess the risk of systemic versus mild reactions, and indicate whether cooking or processing may reduce allergenicity. Non-specific IgE directed against cross-reactive carbohydrate determinants (CCDs) is blocked during the assay, improving specificity and reducing false-positive results. Unlike some allergy tests, the assay does not require patients to stop antihistamines or other symptom-relief medications.

Clinically, the profile is used when IgE-mediated allergy or complex sensitisation patterns are in question—respiratory symptoms, food reactions, oral allergy syndrome, eczema, insect-venom risk assessment, latex allergy, and work-ups for immunotherapy candidacy. Results can direct targeted avoidance, guide safe reintroduction of cooked versus raw foods, support referral decisions, and help avoid unnecessarily restrictive diets by clarifying which components are clinically relevant.

Test specifications

Allergy Solution – ALEX³ Comprehensive IgE Allergy Test

Sample type: Blood Drae or Capillary blood (finger-prick) c

Key markers: Specific IgE to 300 allergens (218 molecular allergens + 82 allergen extracts); semi-quantitative total IgE; coverage of major food, pollen, mite, mould, animal, insect-venom, and latex sources with component-resolved detail.

Turnaround Time: 5 days

Sample Report